Determination of the CCR2-64I/CCR5-59653T haplotype linkage disequilibrium in a sample of Polish population

M Lewandowska; W H Trzeciak; P P Jagodzinski

Determination of the CCR2-64I/CCR5-59653T haplotype linkage disequilibrium in a sample of Polish population

Genetika. 2003 Jun;39(6):831-3.

Authors

M Lewandowska¹, W H Trzeciak, P P Jagodzinski

Affiliation

¹ Department of Biochemistry and Molecular Biology, University of Medical Sciences, 60-781 Poznan, Poland.

PMID: 12884524

Abstract

It has been reported that different polymorphisms in the regulatory regions of CCR5 and in the CCR2 gene of the chemokine receptors are associated with AIDS. We decided to determine the congruence between CCR5-59653T and CCR2-64I alleles in a group of 281 persons. Frequencies of combined CCR5-59653T and CCR2-64I haplotypes were examined in a group of 281 persons. Among 281 individuals 26 (9.3%) and 24 (8.5%) respectively were carriers of the CCR5-59653T and the CCR2-64I alleles. We also found that 24 persons (8.5%) were carriers of combined CCR2-64I/CCR5-59653T allele. The calculation of the congruence revealed that 92.0% of individuals exhibited the same genotype for both CCR2-64I and CCR5-59653T polymorphisms. Our results confirm that linkage between CCR5-59653T and CCR2-64I alleles is not absolute.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acquired Immunodeficiency Syndrome / genetics
Base Sequence
Genetics, Population*
Haplotypes / genetics*
Humans
Linkage Disequilibrium*
Molecular Sequence Data
Poland
Polymorphism, Genetic
Receptors, CCR2
Receptors, CCR5 / genetics*
Receptors, Chemokine / genetics*

Substances

CCR2 protein, human
Receptors, CCR2
Receptors, CCR5
Receptors, Chemokine