Abstract
We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet-derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis-1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT-PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas.
MeSH terms
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Angiogenic Proteins / genetics
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Angiogenic Proteins / metabolism*
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Base Sequence
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DNA, Complementary / genetics
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Fibroblast Growth Factor 2 / genetics
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Fibroblast Growth Factor 2 / metabolism
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Hepatocyte Growth Factor / genetics
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Hepatocyte Growth Factor / metabolism
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Humans
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Neurofibroma / genetics
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Neurofibroma / metabolism*
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Neurofibromatosis 1 / genetics
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Neurofibromatosis 1 / metabolism
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Neurofibromatosis 2 / genetics
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Neurofibromatosis 2 / metabolism
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Proto-Oncogene Proteins c-sis / genetics
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Proto-Oncogene Proteins c-sis / metabolism
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Reverse Transcriptase Polymerase Chain Reaction
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Skin Neoplasms / genetics
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Skin Neoplasms / metabolism*
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Angiogenic Proteins
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DNA, Complementary
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Proto-Oncogene Proteins c-sis
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Vascular Endothelial Growth Factor A
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Fibroblast Growth Factor 2
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Hepatocyte Growth Factor