Abstract
We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of amebic colitis. We found that blockade of TNF-alpha reduced inflammation and intestinal damage in amebic infection, while inhibition of IL-1 reduced cytokine production but had less marked effects on inflammation and disease.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Colon / immunology
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Colon / transplantation
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Dysentery, Amebic / etiology*
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Dysentery, Amebic / immunology
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Dysentery, Amebic / pathology
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Entamoeba histolytica
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Humans
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Inflammation Mediators / antagonists & inhibitors
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Inflammation Mediators / physiology*
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1 / antagonists & inhibitors
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Interleukin-1 / physiology
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Mice
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Mice, SCID
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Sialoglycoproteins / pharmacology
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Transplantation, Heterologous
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / physiology*
Substances
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IL1RN protein, human
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Il1rn protein, mouse
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Inflammation Mediators
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1
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Sialoglycoproteins
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Tumor Necrosis Factor-alpha