Abstract
Objective:
To ascertain whether Ala98Val variant in exon 1 of hepatocyte nuclear factor-1 alpha (HNF-1 alpha) gene is associated with late-onset Type 2 diabetes in Chinese Han nationality.
Methods:
We selected 150 patients with late-onset Type 2 diabetes and 155 controls, and detected Ala98Val variant with polymerase chain reaction-single strand conformational polymorphism(PCR-SSCP) and direct sequencing.
Results:
None of Ala98Val variant was found in all of the subjects.
Conclusion:
The Ala98Val variant doesn't play an important role in late-onset Type 2 diabetes in Chinese Han nationality.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Alanine / genetics
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Amino Acid Substitution
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Asian People
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DNA-Binding Proteins / genetics*
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Diabetes Mellitus, Type 2 / genetics*
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Ethnicity
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Female
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Genetic Variation*
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Hepatocyte Nuclear Factor 1
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Hepatocyte Nuclear Factor 1-alpha
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Humans
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Male
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Middle Aged
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Nuclear Proteins / genetics*
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Polymerase Chain Reaction
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Polymorphism, Single-Stranded Conformational
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Sequence Analysis, DNA
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Transcription Factors / genetics*
Substances
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DNA-Binding Proteins
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HNF1A protein, human
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Hepatocyte Nuclear Factor 1-alpha
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Nuclear Proteins
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Transcription Factors
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Hepatocyte Nuclear Factor 1
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Alanine