Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage

Stroke. 2003 Oct;34(10):e193-5. doi: 10.1161/01.STR.0000089294.85447.1E. Epub 2003 Aug 28.

Abstract

Background and purpose: It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer's disease (AD). Because cerebral amyloid angiopathy-related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH.

Methods: In a case-control study, patients with pathologically verified CAAH, AD patients without intracerebral hemorrhage, and neuropathologically normal control subjects were studied. DNA was extracted from brain tissue, and IL-1A was genotyped. Logistic regression was used to examine the IL-1A polymorphism in CAAH patients with and without AD compared with AD and non-AD control subjects.

Results: There were 42 patients with CAAH, 232 AD patients, and 167 non-AD control subjects. In age-adjusted analyses, there was no association between possession of IL-1A allele 2 and risk of CAAH compared with AD control subjects (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.45 to 1.97; P=0.87) or non-AD control subjects (OR, 0.94; 95% CI, 0.47 to 1.87; P=0.86). Stratifying for the presence of apolipoprotein E epsilon2 or epsilon4 demonstrated the known increased risk of CAAH from these lipoprotein E alleles. Subgroup analyses demonstrated a nonsignificant excess of the IL-1A 2,2 genotype in patients with CAAH and AD compared with those CAAH patients who did not have histological evidence indicating AD (OR, 2.17; 95% CI, 0.15 to 122.3; P=0.64). Comparisons between CAAH patients with AD and AD control subjects and between CAAH patients without AD and non-AD control subjects did not demonstrate an association between CAAH and possession of either the IL-1A allele 2 or the 2,2 genotype.

Conclusions: The IL-1A allele 2 or 2,2 genotype does not appear to be a major risk factor for CAAH.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / pathology
  • Apolipoprotein E2
  • Apolipoprotein E3
  • Apolipoproteins E / genetics
  • Case-Control Studies
  • Cerebral Amyloid Angiopathy / epidemiology
  • Cerebral Amyloid Angiopathy / genetics*
  • Cerebral Hemorrhage / epidemiology
  • Cerebral Hemorrhage / genetics*
  • Comorbidity
  • Gene Frequency
  • Humans
  • Interleukin-1 / genetics*
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic*
  • Reference Values
  • Risk Assessment
  • Risk Factors

Substances

  • Apolipoprotein E2
  • Apolipoprotein E3
  • Apolipoproteins E
  • Interleukin-1