Abstract
Caenorhabditis elegans polycystins LOV-1 and PKD-2 are expressed in the male-specific HOB neuron, and are necessary for sensation of the hermaphrodite vulva during mating. We demonstrate that male vulva location behavior and expression of lov-1 and pkd-2 in the ciliated sensory neuron HOB require the activities of transcription factor EGL-46 and to some extent also EGL-44. This EGL-46- regulated program is specific to HOB and is distinct from a general ciliogenic pathway functioning in all ciliated neurons. The ciliogenic pathway regulator DAF-19 affects downstream components of the HOB-specific program indirectly and is independent of EGL-46 activity. The sensory function of HOB requires the combined action of these two distinct regulatory pathways.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Genetically Modified
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Caenorhabditis elegans / anatomy & histology
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Caenorhabditis elegans / physiology*
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / metabolism*
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Disorders of Sex Development
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Gene Expression Regulation
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Humans
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Male
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Neurons, Afferent / cytology
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Neurons, Afferent / metabolism*
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Proteins / genetics
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Proteins / metabolism*
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Sexual Behavior, Animal / physiology*
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TRPP Cation Channels
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Caenorhabditis elegans Proteins
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DAF-19 protein, C elegans
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EGL-46 protein, C elegans
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Membrane Proteins
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Proteins
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Recombinant Fusion Proteins
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TRPP Cation Channels
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Transcription Factors
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polycystic kidney disease 1 protein
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polycystic kidney disease 2 protein