Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-I-converting enzyme deletion/deletion genotype

Am J Cardiol. 2003 Sep 15;92(6):749-51. doi: 10.1016/s0002-9149(03)00847-6.

Abstract

In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE levels). Angiotensin II levels are similar in both groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Angiotensin I / blood*
  • Angiotensin II / blood
  • Antihypertensive Agents / blood*
  • Female
  • Gene Deletion*
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Hypertension / blood*
  • Hypertension / genetics*
  • Male
  • Middle Aged
  • Peptide Fragments / blood*
  • Peptidyl-Dipeptidase A / genetics*
  • Vasoconstrictor Agents / blood

Substances

  • Antihypertensive Agents
  • Peptide Fragments
  • Vasoconstrictor Agents
  • Angiotensin II
  • Angiotensin I
  • Peptidyl-Dipeptidase A
  • angiotensin I (1-7)