Localization of PMP-22 gene (candidate gene for the Charcot-Marie-Tooth disease 1A) to band 17p11.2 by direct R-banding fluorescence in situ hybridization

E Takahashi; O Takeda; M Himoro; K Nanao; G Takada; K Hayasaka

doi:10.1007/BF01883321

Localization of PMP-22 gene (candidate gene for the Charcot-Marie-Tooth disease 1A) to band 17p11.2 by direct R-banding fluorescence in situ hybridization

Jpn J Hum Genet. 1992 Dec;37(4):303-6. doi: 10.1007/BF01883321.

Authors

E Takahashi¹, O Takeda, M Himoro, K Nanao, G Takada, K Hayasaka

Affiliation

¹ Division of Genetics, National Institute of Radiological Science, Chiba, Japan.

PMID: 1297450
DOI: 10.1007/BF01883321

Abstract

We mapped PMP-22 gene, candidate gene for the Charcot-Marie-Tooth disease (CMT) 1A, by direct R-banding fluorescence in situ hybridization. The signals of PMP-22 probe were localized to chromosome band 17p11.2. The present result was within the map position of the CMT 1A gene by genetic linkage analysis, and strongly indicated that PMP-22 gene is a candidate gene for the CMT 1A.

MeSH terms

Charcot-Marie-Tooth Disease / genetics*
Chromosome Banding / methods
Chromosome Mapping / methods
Chromosomes, Human, Pair 17*
Genes*
Humans
In Situ Hybridization, Fluorescence
Myelin Proteins / genetics*

Substances

Myelin Proteins
PMP22 protein, human