Abstract
A full-length cDNA for the type II human activin receptor was cloned by hybridization from a human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99% identical, at the amino acid level, with the mouse type II activin receptor. The type II human activin receptor consists of an extracellular domain that specifically binds activin A with a Kd of 360 pM, a single-membrane spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Activin Receptors
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Activins
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Amino Acid Sequence
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Animals
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Base Sequence
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Cloning, Molecular
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Gene Library
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Humans
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Inhibins / metabolism*
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Kinetics
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Molecular Sequence Data
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Radioligand Assay
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Receptors, Cell Surface / genetics*
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Receptors, Cell Surface / metabolism*
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Recombinant Proteins / metabolism
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Restriction Mapping
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Transfection
Substances
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Receptors, Cell Surface
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Recombinant Proteins
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Activins
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Inhibins
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Activin Receptors
Associated data
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GENBANK/M93415
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GENBANK/M97581
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GENBANK/M97582
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GENBANK/M97583
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GENBANK/M97584
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GENBANK/M97585
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GENBANK/M97586
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GENBANK/M97587
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GENBANK/M97588
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GENBANK/M97589