Abstract
Chronic granulomatous disease (CGD) encompasses a group of rare inherited disorders characterized by defects in a phagocyte-specific NADPH-oxidase complex that forms the superoxide radical during the respiratory burst. In this chapter, the protein components and cellular biochemistry of the oxidase are reviewed in light of recent genetic and biochemical studies of CGD. The classification and molecular genetic analysis of CGD is discussed. Finally, the use of recombinant human interferon-gamma as a new therapeutic agent for management of the disorder is reviewed.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Free Radicals
-
Granulomatous Disease, Chronic / genetics*
-
Granulomatous Disease, Chronic / immunology
-
Granulomatous Disease, Chronic / therapy
-
Humans
-
Interferon-gamma / therapeutic use
-
Macrophages / immunology
-
NADH, NADPH Oxidoreductases / genetics
-
NADH, NADPH Oxidoreductases / physiology
-
NADPH Oxidases*
-
Neutrophils / immunology
-
Phagocytosis / immunology
-
Respiratory Burst / genetics
-
Respiratory Burst / physiology
-
Superoxides / metabolism
Substances
-
Free Radicals
-
Superoxides
-
Interferon-gamma
-
NADH, NADPH Oxidoreductases
-
NADPH Oxidases
-
superoxide-forming enzyme