Association of a DNA polymorphism of the apolipoprotein A-I/C-III/A-IV gene cluster with hypertriglyceridemia in obese people

Int J Obes Relat Metab Disord. 1992 Nov;16(11):891-6.

Abstract

Hypertriglyceridemia is frequently associated with obesity. In the general Caucasian population, an association of the uncommon S2 allele of a DNA polymorphism of the apolipoprotein (apo) A-I/C-III/A-IV gene cluster with hypertriglyceridemia has been reported. To assess the risk of hypertriglyceridemia associated with the S2 allele in obesity, lipid status and apo A-I/C-III/A-IV genotypes were studied in 90 unrelated Caucasian obese subjects. Age, body mass index, percentage body fat and waist-hip ratio were comparable between genotypes. The frequency of S1/S2 genotype was 35% in the hypertriglyceridemic group versus 11.4% in the normotriglyceridemic group (P < 0.05). The odds ratio of hypertriglyceridemia was 3.7 for obese subjects with the S2 allele and 26.7% of hypertriglyceridemias could be attributed to the S2 allele. Women with the S1/S2 genotype had also significantly higher VLDL- and LDL-cholesterol concentrations. These results suggest that the S2 allele modulates the effects of obesity on lipoproteins and increases the risk of hypertriglyceridemia when obese.

MeSH terms

  • Adult
  • Apolipoprotein A-I / genetics*
  • Apolipoprotein C-III
  • Apolipoproteins A / genetics*
  • Apolipoproteins C / genetics*
  • Base Sequence
  • Cholesterol / blood
  • DNA / analysis*
  • Female
  • Genotype
  • Humans
  • Lipoproteins / blood
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Multigene Family*
  • Obesity / genetics*
  • Triglycerides / blood*

Substances

  • Apolipoprotein A-I
  • Apolipoprotein C-III
  • Apolipoproteins A
  • Apolipoproteins C
  • Lipoproteins
  • Triglycerides
  • apolipoprotein A-IV
  • DNA
  • Cholesterol