Abstract
Seven kidney tumors obtained from patients aged from 5 to 76 years were analyzed by flow cytometry for cell cycle, DNA content and P-glycoprotein expression involved in multidrug resistance. The DNA index seems to be an important criterion since all the tumors were aneuploid. In a case of clear cell carcinoma, two aneuploid clones were identified. In 5 cases of kidney tumors a high proportion of cells in proliferation (S + (G2 + M)) was observed; it was comprised between 13 and 33%. As for P-glycoprotein it was detected only in few tumor cells (5-15%) respectively in a case of clear cell carcinoma and in a case of Wilms' tumor.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Aged
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Aneuploidy
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Biomarkers, Tumor / metabolism*
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Cell Cycle
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Child, Preschool
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DNA, Neoplasm / analysis*
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Female
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Flow Cytometry*
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Humans
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Kidney Neoplasms / chemistry
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Kidney Neoplasms / genetics*
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Kidney Neoplasms / metabolism
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Kidney Neoplasms / pathology
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Male
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Membrane Glycoproteins / biosynthesis*
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Membrane Glycoproteins / genetics
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Middle Aged
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Tumor Cells, Cultured
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Biomarkers, Tumor
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DNA, Neoplasm
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Membrane Glycoproteins
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Neoplasm Proteins