Transgenic animal models of cardiovascular disease

Curr Opin Biotechnol. 1992 Dec;3(6):637-40. doi: 10.1016/0958-1669(92)90008-7.

Abstract

Transgenic experimentation has become a crucial part of hypertension and atherosclerosis research, and is growing more important in several other areas of cardiovascular disease. It has recently made a particular contribution to understanding the role of the renin-angiotensin system in controlling hypertension. The study of blood pressure regulation, cardiac hypertrophy, atherogenesis and thrombosis are also benefiting from the transgenic approach.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified*
  • Apolipoprotein A-I / metabolism
  • Arteriosclerosis / genetics
  • Arteriosclerosis / physiopathology
  • Blood Pressure
  • Cardiomegaly / genetics
  • Cardiomegaly / physiopathology
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / physiopathology*
  • Cholesterol, HDL / blood
  • Disease Models, Animal
  • Humans
  • Hypertension / genetics
  • Hypertension / physiopathology
  • Mice
  • Mice, Transgenic
  • Renin / genetics
  • Renin-Angiotensin System / genetics

Substances

  • Apolipoprotein A-I
  • Cholesterol, HDL
  • Renin