Marrow fibrosis associated with a Philadelphia chromosome

Cancer Genet Cytogenet. 1992 Mar;59(1):89-92. doi: 10.1016/0165-4608(92)90167-7.

Abstract

Three patients had marked marrow fibrosis and an apparent Philadelphia (Ph) chromosome. Hematologic, cytogenetic, and molecular studies demonstrated the heterogeneity of such cases, including the first example of clinically typical myelofibrosis (MF) associated with a bcr gene rearrangement characteristic of chronic myelogenous leukemia (CML).

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bone Marrow / pathology*
  • Bone Marrow Transplantation
  • Female
  • Fibrosis
  • Humans
  • Interferons / therapeutic use
  • Karyotyping
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • Male
  • Middle Aged
  • Philadelphia Chromosome*
  • Primary Myelofibrosis / genetics*
  • Primary Myelofibrosis / pathology
  • Primary Myelofibrosis / therapy

Substances

  • Interferons