Molecular cytogenetic analysis of a complex t(10;22;11) translocation in Ewing's sarcoma

F Speleman; N Van Roy; J Wiegant; A M Dierick; D Uyttendaele; J G Leroy

doi:10.1002/gcc.2870040214

Molecular cytogenetic analysis of a complex t(10;22;11) translocation in Ewing's sarcoma

Genes Chromosomes Cancer. 1992 Mar;4(2):188-91. doi: 10.1002/gcc.2870040214.

Authors

F Speleman¹, N Van Roy, J Wiegant, A M Dierick, D Uyttendaele, J G Leroy

Affiliation

¹ Department of Medical Genetics, University Hospital, Ghent, Belgium.

PMID: 1373321
DOI: 10.1002/gcc.2870040214

Abstract

Fluorescence in situ hybridization (FISH) using chromosome-specific plasmid libraries and chromosome region-specific DNA markers allowed the characterization of a t(10;22;11) (p11.2;q12;q24) in a Ewing's sarcoma (ES). This study illustrates the usefulness of molecular cytogenetic analysis of ES, especially for determining the localization of the translocated 11q24-25 segment in complex or variant translocations.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bone Neoplasms / genetics*
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 8
Female
Humans
Karyotyping
Microscopy, Fluorescence
Nucleic Acid Hybridization
Sarcoma, Ewing / genetics*
Tibia / pathology
Translocation, Genetic*
Tumor Cells, Cultured