Abstract
Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33-qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33-qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki-I lymphomas.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Chromosome Mapping
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Chromosomes, Human, Pair 5*
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Fibroblast Growth Factors*
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Gene Expression Regulation, Leukemic
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Genes
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Humans
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Leukemia / genetics
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Leukemia / pathology
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Leukemia, Erythroblastic, Acute / genetics
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Leukemia, Erythroblastic, Acute / pathology
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Lymphoma / genetics
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Lymphoma / pathology
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Neoplasm Proteins / genetics
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Polymerase Chain Reaction
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Protein-Tyrosine Kinases / genetics*
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Receptor, Fibroblast Growth Factor, Type 4
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Receptors, Cell Surface / genetics*
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Receptors, Fibroblast Growth Factor
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Translocation, Genetic
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Tumor Cells, Cultured / ultrastructure
Substances
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Neoplasm Proteins
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Receptors, Cell Surface
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Receptors, Fibroblast Growth Factor
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Fibroblast Growth Factors
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FGFR4 protein, human
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Protein-Tyrosine Kinases
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Receptor, Fibroblast Growth Factor, Type 4