Rare point mutation at codon 301 and 969 of FMS/M-CSF receptor in acute myelomonocytic and monocytic leukemia

T Natazuka; T Matsui; M Ito; H Nakata; T Nakagawa; H Nakamura; T Masaoka; T Isobe; Y Nakao

doi:10.1016/0145-2126(92)90182-7

Rare point mutation at codon 301 and 969 of FMS/M-CSF receptor in acute myelomonocytic and monocytic leukemia

Leuk Res. 1992;16(5):541-3. doi: 10.1016/0145-2126(92)90182-7.

Authors

T Natazuka¹, T Matsui, M Ito, H Nakata, T Nakagawa, H Nakamura, T Masaoka, T Isobe, Y Nakao

Affiliation

¹ Department of Medicine, Kobe University School of Medicine, Japan.

PMID: 1385636
DOI: 10.1016/0145-2126(92)90182-7

Abstract

We have investigated whether point mutations occurred at codon 301 or 969 of FMS (M-CSF receptor) in 19 patients with acute myelomonocytic (M4) and monocytic leukemia (M5). Nineteen peripheral blood and bone marrow blood samples collected from M4 and M5 patients were examined by using polymerase chain reaction and hybridization to allele specific oligonucleotide probes. Mutations at codon 301 and 969 of FMS were not detected in any samples. FMS gene mutations at codon 301 and 969 were rarely involved in M4 and M5 patients in Japan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Codon / genetics*
Humans
Leukemia, Monocytic, Acute / genetics*
Leukemia, Myelomonocytic, Acute / genetics*
Molecular Sequence Data
Mutation / genetics*
Polymerase Chain Reaction
Receptor, Macrophage Colony-Stimulating Factor / genetics*

Substances

Codon
Receptor, Macrophage Colony-Stimulating Factor