Alterations of the p53 gene in Philadelphia chromosome-positive leukemia including chronic myelogenous leukemia and acute leukemia

S Tanaka; S Misawa; H Nishigaki; K Ishizaki; T Takashima; H Nakagawa; S Horiike; K Kashima; J Inazawa; T Abe

Alterations of the p53 gene in Philadelphia chromosome-positive leukemia including chronic myelogenous leukemia and acute leukemia

Int J Hematol. 1992 Aug;56(1):1-7.

Authors

S Tanaka¹, S Misawa, H Nishigaki, K Ishizaki, T Takashima, H Nakagawa, S Horiike, K Kashima, J Inazawa, T Abe

Affiliation

¹ Third Department of Medicine, Kyoto Prefectural University of Medicine, Japan.

PMID: 1391801

Abstract

We analyzed the structural alteration of the p53 gene, by Southern blotting with conventional and/or pulsed-field gel electrophoresis, in patients with Philadelphia chromosome-positive leukemia (chronic myelogenous leukemia; CML, 34 cases and acute leukemia; AL, 5 cases). We found an alteration of the p53 gene in one of 5 AL patients. Loss of heterozygosity was detected in two CML patients with i(17q) chromosome, but we could find no other alterations in the remaining CML patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Adult
Aged
Aged, 80 and over
Blotting, Southern
Child
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Male
Middle Aged