Abstract
The human immunodeficiency virus establishes an intimate interaction with the immune system. The virus can use cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (Il-1), to regulate its own expression by modifying the normal immunoregulatory network. We demonstrate that mRNA of the cytokine TNF-alpha from peripheral blood mononuclear cells is overexpressed in virtually all patients with AIDS who do not have active opportunistic infections compared with uninfected volunteers (p < 0.0001). This overexpression correlates with elevated mRNA levels of the recently discovered GRO (p < 0.05), a cytokine involved in the inflammatory response.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / genetics
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Acquired Immunodeficiency Syndrome / immunology*
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Actins / analysis
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Blotting, Northern
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Chemokine CXCL1
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Chemokines, CXC*
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Chemotactic Factors / biosynthesis
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Chemotactic Factors / genetics*
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Gene Expression*
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Growth Substances / biosynthesis
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Growth Substances / genetics*
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Humans
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Intercellular Signaling Peptides and Proteins*
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Probability
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Tumor Necrosis Factor-alpha / biosynthesis
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Tumor Necrosis Factor-alpha / genetics*
Substances
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Actins
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CXCL1 protein, human
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Chemokine CXCL1
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Chemokines, CXC
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Chemotactic Factors
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Growth Substances
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Intercellular Signaling Peptides and Proteins
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RNA, Messenger
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Tumor Necrosis Factor-alpha