Abstract
Short tandem repeats (STRs) are highly informative loci within the human genome, consisting of short nucleotide sequences tandemly repeated in variable numbers. This results in different alleles of variable length. Herein we describe two STRS located 5' to the beta-globin gene. They can be detected by non radioactive methods and may be used to make prenatal diagnosis of beta-thalassemia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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DNA, Satellite / analysis*
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Feasibility Studies
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Female
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Fetal Diseases / diagnosis*
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Fetal Diseases / genetics
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Genes
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Genetic Markers*
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Globins / genetics*
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Humans
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Molecular Sequence Data
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Polymerase Chain Reaction
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Pregnancy
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Prenatal Diagnosis / methods*
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Repetitive Sequences, Nucleic Acid*
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beta-Thalassemia / diagnosis*
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beta-Thalassemia / genetics
Substances
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DNA, Satellite
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Genetic Markers
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Globins