Oncogene HER-2 in canine mammary gland carcinomas: an immunohistochemical and chromogenic in situ hybridization study

J Martin de las Mulas; J Ordás; Y Millán; V Fernández-Soria; S Ramón y Cajal

doi:10.1023/a:1024929730165

Oncogene HER-2 in canine mammary gland carcinomas: an immunohistochemical and chromogenic in situ hybridization study

Breast Cancer Res Treat. 2003 Aug;80(3):363-7. doi: 10.1023/a:1024929730165.

Authors

J Martin de las Mulas¹, J Ordás, Y Millán, V Fernández-Soria, S Ramón y Cajal

Affiliation

¹ Department of Comparative Pathology, Veterinary School, University of Córdoba, Córdoba, Spain. an1magoj@uco.es

PMID: 14503809
DOI: 10.1023/a:1024929730165

Abstract

Immunohistochemical (IHC) HER-2/neu protein overexpression was found in 17.6% of canine mammary gland carcinomas, a percentage similar to that observed in human breast carcinoma, but there was no gene amplification by chromogenic in situ hybridization (CISH). Canine mammary carcinoma would be a suitable natural model of that subset of human breast carcinomas with HER-2 protein overexpression without gene amplification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Dog Diseases / genetics*
Dog Diseases / pathology
Dogs
Female
Gene Amplification
Gene Expression Regulation, Neoplastic*
Humans
Immunohistochemistry / veterinary
In Situ Hybridization / veterinary
Mammary Neoplasms, Animal / genetics*
Mammary Neoplasms, Animal / pathology
Receptor, ErbB-2 / biosynthesis*
Receptor, ErbB-2 / genetics*

Substances

Receptor, ErbB-2