Microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, Taiwan

Po-Ren Hsueh; Cheng-Hsiang Hsiao; Shiou-Hwei Yeh; Wei-Kung Wang; Pei-Jer Chen; Jin-Town Wang; Shan-Chwen Chang; Chuan-Liang Kao; Pan-Chyr Yang; SARS Research Group of National Taiwan University College of Medicine and National Taiwan University Hospital

doi:10.3201/eid0909.030367

Microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, Taiwan

Emerg Infect Dis. 2003 Sep;9(9):1163-7. doi: 10.3201/eid0909.030367.

Authors

Po-Ren Hsueh¹, Cheng-Hsiang Hsiao, Shiou-Hwei Yeh, Wei-Kung Wang, Pei-Jer Chen, Jin-Town Wang, Shan-Chwen Chang, Chuan-Liang Kao, Pan-Chyr Yang; SARS Research Group of National Taiwan University College of Medicine and National Taiwan University Hospital

Affiliation

¹ National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

Abstract

The genome of one Taiwanese severe acute respiratory syndrome-associated coronavirus (SARS-CoV) strain (TW1) was 29,729 nt in length. Viral RNA may persist for some time in patients who seroconvert, and some patients may lack an antibody response (immunoglobulin G) to SARS-CoV <21 days after illness onset. An upsurge of antibody response was associated with the aggravation of respiratory failure.

MeSH terms

Adult
Antibodies, Viral / isolation & purification
Communicable Diseases, Emerging / epidemiology
Communicable Diseases, Emerging / immunology
Communicable Diseases, Emerging / physiopathology*
Female
Genome, Viral*
Humans
Male
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction
Severe Acute Respiratory Syndrome / epidemiology
Severe Acute Respiratory Syndrome / immunology
Severe Acute Respiratory Syndrome / physiopathology*
Severe acute respiratory syndrome-related coronavirus / genetics*
Severe acute respiratory syndrome-related coronavirus / immunology
Severe acute respiratory syndrome-related coronavirus / isolation & purification
Taiwan / epidemiology

Substances

Antibodies, Viral