Abstract
We determined immune cross-recognition and the degree of Tat conservation in patients infected by local human immunodeficiency virus (HIV) type 1 strains. The data indicated a similar prevalence of total and epitope-specific anti-Tat IgG in 578 serum samples from HIV-infected Italian (n=302), Ugandan (n=139), and South African (n=137) subjects, using the same B clade Tat protein that is being used in vaccine trials. In particular, anti-Tat antibodies were detected in 13.2%, 10.8%, and 13.9% of HIV-1-infected individuals from Italy, Uganda, and South Africa, respectively. Sequence analysis results indicated a high similarity of Tat from the different circulating viruses with BH-10 Tat, particularly in the 1-58 amino acid region, which contains most of the immunogenic epitopes. These data indicate an effective cross-recognition of a B-clade laboratory strain-derived Tat protein vaccine by individuals infected with different local viruses, owing to the high similarity of Tat epitopes.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Vaccines
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Adolescent
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Adult
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Amino Acid Sequence
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Conserved Sequence*
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Cross Reactions
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Cross-Sectional Studies
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Epitope Mapping
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Female
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Gene Products, tat / chemistry
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Gene Products, tat / genetics*
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Gene Products, tat / immunology*
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HIV Antibodies / blood*
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HIV Infections / immunology
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HIV Infections / virology
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HIV-1 / classification*
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HIV-1 / genetics
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HIV-1 / immunology
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Humans
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Italy
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Male
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Middle Aged
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Molecular Sequence Data
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Phylogeny
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Sequence Analysis, DNA
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South Africa
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Uganda
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tat Gene Products, Human Immunodeficiency Virus
Substances
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AIDS Vaccines
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Gene Products, tat
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HIV Antibodies
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tat Gene Products, Human Immunodeficiency Virus
Associated data
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GENBANK/AY193980
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