Abstract
Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Genes, Tumor Suppressor / physiology*
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Humans
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Membrane Proteins / genetics
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Membrane Proteins / physiology*
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Neoplasms / genetics
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Neoplasms / physiopathology*
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Oncogenes / physiology*
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Receptors, Notch
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Signal Transduction / genetics
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Signal Transduction / physiology
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Trans-Activators / genetics
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Trans-Activators / physiology*
Substances
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Membrane Proteins
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Receptors, Notch
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Trans-Activators