Dopamine receptor D2 -141C Insertion/Deletion polymorphism in a Finnish population with schizophrenia

Olli Kampman; Sami Anttila; Ari Illi; Terho Lehtimäki; Kari M Mattila; Markus Roivas; Esa Leinonen

doi:10.1016/s0165-1781(03)00201-4

Dopamine receptor D2 -141C Insertion/Deletion polymorphism in a Finnish population with schizophrenia

Psychiatry Res. 2003 Nov 1;121(1):89-92. doi: 10.1016/s0165-1781(03)00201-4.

Authors

Olli Kampman¹, Sami Anttila, Ari Illi, Terho Lehtimäki, Kari M Mattila, Markus Roivas, Esa Leinonen

Affiliation

¹ Department of Psychiatry, University of Tampere, Medical School, Tampere, FIN-33014, Finland. olli.kampman@uta.fi

PMID: 14572625
DOI: 10.1016/s0165-1781(03)00201-4

Abstract

We examined the occurrence of the -141C Ins/Del polymorphism in 93 Finnish patients with schizophrenia. In comparison with previous studies with Japanese and Caucasian populations, the incidence of this polymorphism was unexpectedly low. The findings suggest that the frequency of the -141C Ins/Del polymorphism is lower in Northern Europe compared to other Caucasian and Japanese populations.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Chromosome Deletion*
Cross-Cultural Comparison
Cytosine / metabolism*
Europe
Finland
Gene Frequency / genetics
Genetics, Population
Genotype
Humans
Japan
Mutagenesis, Insertional*
Odds Ratio
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics
Receptors, Dopamine D2 / genetics*
Schizophrenia / diagnosis
Schizophrenia / genetics*
Schizophrenic Psychology*

Substances

Receptors, Dopamine D2
Cytosine