Abstract
Chronic pain is often difficult to treat effectively. We have exploited the high affinity of herpes simplex virus (HSV) for peripheral sensory neurons to create HSV-based vectors for the treatment of chronic pain. We have demonstrated that an HSV-based vector expressing proenkephalin reduces pain-related responses in rodent models of inflammatory pain, neuropathic pain, and pain resulting from cancer in bone. A human trial has been proposed.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chronic Disease
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Disease Models, Animal
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Enkephalins / metabolism
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Ganglia, Spinal / cytology
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Ganglia, Spinal / metabolism
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Ganglia, Spinal / virology
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Gene Transfer Techniques
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Genetic Therapy*
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Genetic Vectors
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Humans
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Ligation / methods
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Pain / veterinary
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Pain / virology
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Pain Management*
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Pain Measurement
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Pain Threshold
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Protein Precursors / metabolism
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Rats
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Simplexvirus / genetics*
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Time Factors
Substances
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Enkephalins
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Protein Precursors
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proenkephalin