Abstract
In acute lymphoblastic leukemia (ALL) abnormal karyotypes frequently constitute a minor part of the dividing cells, and the origin of metaphases in normal diploid cases remains obscure. We used a combination of immunomagnetic cell separation and chromosome preparation (ICSCP) to focus on the metaphases of interest and to assign the chromosome findings to CD19+ or CD7+ leukemia cells.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antigens, CD19 / analysis*
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Antigens, CD7 / analysis*
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Antigens, Neoplasm / analysis*
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Bone Marrow Cells / immunology
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Bone Marrow Cells / pathology
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Cell Lineage
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Chromosome Painting
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Female
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Humans
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Immunomagnetic Separation*
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Immunophenotyping / methods*
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Male
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Middle Aged
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Neoplastic Stem Cells / immunology
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Neoplastic Stem Cells / pathology*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
Substances
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Antigens, CD19
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Antigens, CD7
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Antigens, Neoplasm