Abstract
Human epidermal growth factor receptor-2 (HER2/neu; erbB2) belongs to a family of four transmembrane receptor tyrosine kinases involved in signal transduction pathways that regulate cell growth and proliferation. Amplification or overexpression of HER2/neu occurs in about 30% of human breast and ovarian cancers and is associated with a poor clinical outcome, including short survival time and short time to relapse. Recent advances in our understanding of HER2/neu signaling pathways have greatly increased our knowledge of breast cancer tumorigenesis and have provided new targets for treating breast and ovarian tumors that overexpress HER2/neu. This review will focus on the signaling network mediated by HER2/neu in breast cancer and discuss our understanding of these pathways, which seem to be particularly important in mediating cell survival and growth under a wide variety of circumstances in breast cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Antineoplastic Agents / pharmacology*
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Apoptosis
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Breast Neoplasms* / drug therapy
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Breast Neoplasms* / genetics
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Breast Neoplasms* / metabolism
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Breast Neoplasms* / pathology
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Cell Cycle
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Cytoskeletal Proteins
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Gene Expression
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Gene Expression Regulation, Neoplastic
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Genes, erbB-2
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Humans
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NF-kappa B
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Nuclear Proteins*
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Protein Serine-Threonine Kinases*
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-akt
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Proto-Oncogene Proteins c-mdm2
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Receptor, ErbB-2* / physiology
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Signal Transduction* / drug effects
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Trans-Activators
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Tumor Suppressor Protein p53
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Wnt Proteins
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Zebrafish Proteins*
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beta Catenin
Substances
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Antineoplastic Agents
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CTNNB1 protein, human
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Cytoskeletal Proteins
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NF-kappa B
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Nuclear Proteins
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Proto-Oncogene Proteins
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Trans-Activators
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Tumor Suppressor Protein p53
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Wnt Proteins
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Zebrafish Proteins
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beta Catenin
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2
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Protein-Tyrosine Kinases
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Receptor, ErbB-2
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt