Objective: To assess the relationship between SULT1A1 Arg213His polymorphism and breast cancer in Hans of Chinese women, as well as the interaction of the polymorphism and related risk factor of breast cancer.
Methods: Distribution of Arg213His polymorphism of the SULT1A1 gene was detected by using PCR-RFLP in 209 cases of breast cancer and 426 matched healthy controls. The OR of susceptibility of SULT1A1 genotypes to breast cancer and the r value of interaction with exposure factors using multivariate logistic regression.
Results: (1) There was no significant difference in genotype of Arg/Arg, Arg/His and His/His of SULT1A1 between case and control (P = 0.12). The frequency of His allele was 13.6% and 9.5% in were determined case and control, respectively, P = 0.03; (2) Compared with Arg/Arg genotype, the risk of Arg/His and His/His was increased, P for trend = 0.04; The OR of His allele (Arg/His + His/His) was 2.60 (95% CI: 1.12 - 6.05, P = 0.04); (3) As for the interaction between gene and related exposure factors, His allele strengthen the effect of endogenous estrogen exposure (interaction index r > 1), and weaken the effect of factors related to exposure of some procarcinogen in dietary (r < 1), both being multiplicative interaction model.
Conclusion: SULT1A1 His allele is positively associated with the risk of breast cancer, and an interaction exist between this allele and related exposure factors.