Allergy to natural rubber latex affects people routinely exposed to rubber products. Groups thought to be at highest risk include atopics, health care workers, rubber industry workers, and individuals who have undergone multiple surgical procedures, especially those with spina bifida. Allergy to latex is a type I, immediate, IgE-mediated reaction that can lead to anaphylaxis and death. The prevalence, risk factors, clinical manifestations, diagnosis, and management of latex allergy are summarized in this review.