Abstract
Our emerging understanding of the IL-2/IL-2R system opens the possibility for more specific immunotherapy of CTCL. This understanding, taken in conjunction with the ability to produce humanized antibodies to the IL-2R subunit by genetic engineering; to arm these antibodies, as well as IL-2 itself with toxins or with alpha- and beta-emitting radionuclides; and to modulate IL-2R subunits to optimize targeting of these agents provides a rational therapeutic strategy for the treatment of IL-2R-expressing CTCL. Although most of these studies were conducted in HTLV-1-associated T-cell lymphomas or CTCL, it is likely that these agents may be applicable to other T-cell lymphomas, including the anaplastic large cell lymphomas, peripheral T-cell lymphomas, and the natural killer lymphomas, because these cells express the IL-2 receptor.
MeSH terms
-
Antibodies, Monoclonal / therapeutic use
-
Clinical Trials as Topic
-
Diphtheria Toxin / therapeutic use
-
Drug Delivery Systems
-
Gene Expression Regulation, Neoplastic / drug effects
-
Humans
-
Immunoconjugates / therapeutic use
-
Immunotherapy
-
Immunotoxins / therapeutic use
-
Interleukin-2 / physiology
-
Interleukin-2 / therapeutic use
-
Lymphoma, T-Cell, Cutaneous / drug therapy*
-
Lymphoma, T-Cell, Cutaneous / metabolism
-
Lymphoma, T-Cell, Cutaneous / radiotherapy
-
Neoplasm Proteins / antagonists & inhibitors*
-
Neoplasm Proteins / immunology
-
Neoplasm Proteins / physiology
-
Protein Isoforms / antagonists & inhibitors
-
Protein Isoforms / genetics
-
Protein Subunits
-
Receptors, Interleukin-2 / antagonists & inhibitors*
-
Receptors, Interleukin-2 / genetics
-
Receptors, Interleukin-2 / immunology
-
Receptors, Interleukin-2 / physiology
-
Recombinant Fusion Proteins / therapeutic use
-
Retinoids / pharmacology
-
Retinoids / therapeutic use
-
Skin Neoplasms / drug therapy*
-
Skin Neoplasms / metabolism
-
Skin Neoplasms / radiotherapy
Substances
-
Antibodies, Monoclonal
-
Diphtheria Toxin
-
Immunoconjugates
-
Immunotoxins
-
Interleukin-2
-
Neoplasm Proteins
-
Protein Isoforms
-
Protein Subunits
-
Receptors, Interleukin-2
-
Recombinant Fusion Proteins
-
Retinoids
-
interleukin 2-diphtheria toxin