Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease

Jian Wang; Chunying Zhao; Biao Chen; Zhuo-Lin Liu

doi:10.1016/j.neulet.2003.11.006

Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease

Neurosci Lett. 2004 Jan 30;355(3):193-6. doi: 10.1016/j.neulet.2003.11.006.

Authors

Jian Wang¹, Chunying Zhao, Biao Chen, Zhuo-Lin Liu

Affiliation

¹ Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, PR China. wangj@pharm.sunysb.edu

PMID: 14732464
DOI: 10.1016/j.neulet.2003.11.006

Abstract

The authors conducted a case-control study of Parkinson's disease patients with and without visual hallucinations to investigate associations of the polymorphisms of the dopamine receptors D2 32806 C>T (Taq1A), D3 Ser9Gly and Msp1, D5 978T>C and dopamine transporter 3'-UTR 40 bp VNTR with visual hallucinations in Parkinson's disease. No significant differences were found between hallucinators and non-hallucinators in either the genotypic or allelic distributions. Our data suggest that the loci investigated here are not associated with the visual hallucinogenesis in Parkinson's disease.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alleles
Case-Control Studies
Chi-Square Distribution
Dopamine Plasma Membrane Transport Proteins
Female
Follow-Up Studies
Gene Frequency / genetics
Genotype
Hallucinations / genetics*
Humans
Male
Membrane Glycoproteins*
Membrane Transport Proteins / genetics*
Middle Aged
Nerve Tissue Proteins*
Parkinson Disease / genetics*
Polymorphism, Genetic / genetics*
Receptors, Dopamine / genetics*
Statistics, Nonparametric

Substances

Dopamine Plasma Membrane Transport Proteins
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
Receptors, Dopamine