Abstract
Tumor necrosis factor-alpha (TNFalpha) gene polymorphisms have been reported to be associated with Alzheimer's disease (AD) in Caucasian populations. Three TNFalpha polymorphisms (-857, -863, and -1,031) were studied in a Chinese population. A high-risk TNFalpha haplotype (-1,031C-863C-857C) with an odds ratio of 2.54 (95% CI 1.37 to 4.79) for AD was identified. No interaction effect of APOE and TNFalpha genotypes was found, but both acted as important risk factors for AD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Alleles
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics*
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Apolipoproteins E / genetics
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Case-Control Studies
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China
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DNA Mutational Analysis
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Female
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Gene Frequency
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Genetic Predisposition to Disease
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Genotype
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Haplotypes / genetics
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Humans
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Male
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Middle Aged
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Odds Ratio
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Polymorphism, Genetic*
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Risk
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Tumor Necrosis Factor-alpha / genetics*
Substances
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Apolipoproteins E
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Tumor Necrosis Factor-alpha