Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2

J Immunol. 2004 Feb 15;172(4):2006-10. doi: 10.4049/jimmunol.172.4.2006.

Abstract

The receptor for IL-26 (AK155), a cytokine of the IL-10 family, has not previously been defined. We demonstrate that the active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20R1 and IL-10R2. Signaling through the IL-26R results in activation of STAT1 and STAT3 which can be blocked by neutralizing Abs against IL-20R1 or IL-10R2. IL-10R2 is broadly expressed on a wide variety of tissues, whereas only a limited number of tissues express IL-20R1. Therefore, the ability to respond to IL-26 is restricted by the expression of IL-20R1. IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Cell Line, Tumor
  • DNA-Binding Proteins / metabolism
  • Dimerization
  • HT29 Cells
  • Humans
  • Interleukin-10 / metabolism*
  • Interleukins / metabolism*
  • Interleukins / physiology*
  • Organ Specificity / genetics
  • Organ Specificity / immunology
  • Protein Isoforms / biosynthesis
  • Protein Isoforms / genetics
  • Protein Isoforms / physiology
  • Receptors, Interleukin / biosynthesis
  • Receptors, Interleukin / genetics
  • Receptors, Interleukin / physiology*
  • Receptors, Interleukin-10
  • STAT1 Transcription Factor
  • STAT3 Transcription Factor
  • Signal Transduction / immunology*
  • Trans-Activators / metabolism

Substances

  • DNA-Binding Proteins
  • IL26 protein, human
  • Interleukins
  • Protein Isoforms
  • Receptors, Interleukin
  • Receptors, Interleukin-10
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Trans-Activators
  • Interleukin-10
  • interleukin 20