Abstract
We examined the distribution of Pael-R, a newly identified substrate for Parkin, in Parkinson's disease (PD) and multiple system atrophy (MSA). Pael-R, Parkin, alpha-synuclein, and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael-R was localized in the core of LBs. Parkin and alpha-synuclein accumulated in the halo, neuronal cell bodies, and processes. These findings potentially suggest the involvement of Pael-R in LB formation, and protection role of Parkin in Pael-R-mediated neurotoxicity in PD. The absence of Pael-R and Parkin in glial cytoplasmic inclusions (GCIs) in MSA implies a distinct pathway involved in the formation of LBs and GCIs.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Aged, 80 and over
-
Brain / cytology
-
Brain / metabolism
-
Female
-
Humans
-
Immunohistochemistry / methods
-
Lewy Bodies / metabolism*
-
Male
-
Middle Aged
-
Multiple System Atrophy / metabolism
-
Nerve Tissue Proteins / metabolism
-
Neurites / metabolism
-
Neurons / metabolism
-
Parkinson Disease / metabolism*
-
Receptors, G-Protein-Coupled / metabolism*
-
Synucleins
-
Ubiquitin / metabolism
-
Ubiquitin-Protein Ligases / metabolism
-
alpha-Synuclein
Substances
-
GPR37 receptor, human
-
Nerve Tissue Proteins
-
Receptors, G-Protein-Coupled
-
SNCA protein, human
-
Synucleins
-
Ubiquitin
-
alpha-Synuclein
-
Ubiquitin-Protein Ligases
-
parkin protein