Recently, a semiquantitative enzyme-linked immunoassay for detecting IgG or IgM class autoantibody to beta2-GPI for use as an aid in the diagnosis of certain autoimmune or thrombotic disorders. We evaluated the prevalence of anti-beta2-GPI antibody and its relation to plasma beta2-GPI levels and occurrence of thrombosis in 69 patients with liver cirrhosis. As expected, plasma beta2-GPI levels were lower in the patients with liver cirrhosis and correlated with Child classification. Anti-beta2-GPI antibodies were positive in 11 (15.9%) patients. However, there were no differences in beta2-GPI levels, platelet counts, and thrombosis between positive and negative groups for anti-beta2-GPI antibodies.