Abstract
The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology*
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Genes, Bacterial
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Lung / pathology
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Male
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Mice
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Mice, Inbred BALB C
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Mice, SCID
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Mutation
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / pathogenicity*
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Mycobacterium tuberculosis / physiology*
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Sigma Factor / genetics
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Sigma Factor / physiology*
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Transcription Factors / genetics
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Transcription Factors / physiology*
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Tuberculosis, Pulmonary / immunology
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Tuberculosis, Pulmonary / microbiology
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Tuberculosis, Pulmonary / pathology
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Virulence / genetics
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Virulence / physiology
Substances
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Bacterial Proteins
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Sigma Factor
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Transcription Factors
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sporulation-specific sigma factors