Abstract
The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder.
MeSH terms
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Anemia / etiology*
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Animals
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Antimicrobial Cationic Peptides / biosynthesis*
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Cells, Cultured
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Cytokines / metabolism*
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Hepatocytes / metabolism
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Hepcidins
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Humans
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Inflammation / complications
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Inflammation / metabolism*
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Interleukin-6 / metabolism*
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Interleukin-6 / pharmacology
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Intestinal Mucosa / metabolism
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Iron / metabolism
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Macrophages / metabolism
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Mice
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Models, Biological
Substances
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Antimicrobial Cationic Peptides
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Cytokines
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HAMP protein, human
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Hamp protein, mouse
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Hepcidins
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Interleukin-6
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Iron