Bcl-6 gene mutations in primary cutaneous B-cell lymphomas

Umberto Gianelli; Amilcare Cerri; Barbara Cassani; Laura Moneghini; Paola Rafaniello Raviele; Emilio Berti; Silvano Bosari

Bcl-6 gene mutations in primary cutaneous B-cell lymphomas

Haematologica. 2004 May;89(5):624-6.

Authors

Umberto Gianelli, Amilcare Cerri, Barbara Cassani, Laura Moneghini, Paola Rafaniello Raviele, Emilio Berti, Silvano Bosari

PMID: 15136235

Abstract

We analyzed mutations in the 5' non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.

Publication types

Letter

MeSH terms

5' Untranslated Regions / genetics
Adult
Aged
Aged, 80 and over
Female
Humans
Lymphoma, B-Cell / genetics*
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Proto-Oncogene Proteins c-bcl-6 / genetics*
Skin Neoplasms / genetics*

Substances

5' Untranslated Regions
Proto-Oncogene Proteins c-bcl-6