[Feeding disorders in 5-HT4 receptor knockout mice]

J Soc Biol. 2004;198(1):37-49.
[Article in French]

Abstract

To study the functional contributions of the 5-HT4 receptor subtype of serotonin (5-HT), we have generated knockout mice lacking the 5-HT4 receptor gene. The male mutant mice exhibit a hyposensitivity to anorexic stress. Our recent data indicate that the pharmacological inactivation, using a systemic injection of the 5-HT4 receptor antagonist RS39604 (0.5 mg/kg), suppressed restraint stress-induced anorexia in wild-type female mice. In parallel, the same treatment reduced the 3,4-N-methylenedioxymethamphetamine (" ecstasy", 10 mg/kg)-induced anorexia in male wild-type mice. Our neurochemical analyses suggest that the mechanisms underlying feeding disorders in 5-HT4 receptor knockout mice are related to a lesser efficacy of 5-HT (hypothalamus, nucleus accumbens), leptin and the cocaine-amphetamine related transcript to reduce food intake following stress.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Anorexia / etiology
  • Anorexia / genetics
  • Anorexia / prevention & control
  • Appetite / drug effects
  • Appetite / physiology
  • Chromatography, High Pressure Liquid
  • Corticosterone / physiology
  • Feeding and Eating Disorders / genetics*
  • Feeding and Eating Disorders / physiopathology
  • Gene Expression Regulation / drug effects
  • Leptin / biosynthesis
  • Leptin / genetics
  • Limbic System / drug effects
  • Limbic System / physiopathology
  • Male
  • Mice
  • Mice, Knockout
  • N-Methyl-3,4-methylenedioxyamphetamine / toxicity
  • Nerve Tissue Proteins / biosynthesis
  • Nerve Tissue Proteins / genetics
  • Piperidines / pharmacology
  • Propane / analogs & derivatives*
  • Propane / pharmacology
  • Receptors, Serotonin, 5-HT4 / deficiency*
  • Receptors, Serotonin, 5-HT4 / genetics
  • Receptors, Serotonin, 5-HT4 / physiology
  • Restraint, Physical
  • Reverse Transcriptase Polymerase Chain Reaction
  • Serotonin / physiology*
  • Serotonin 5-HT4 Receptor Antagonists
  • Serotonin Antagonists / pharmacology
  • Stress, Psychological / complications
  • Stress, Psychological / physiopathology

Substances

  • Leptin
  • Nerve Tissue Proteins
  • Piperidines
  • RS 39604
  • Serotonin 5-HT4 Receptor Antagonists
  • Serotonin Antagonists
  • cocaine- and amphetamine-regulated transcript protein
  • Receptors, Serotonin, 5-HT4
  • Serotonin
  • N-Methyl-3,4-methylenedioxyamphetamine
  • Propane
  • Corticosterone