Abstract
This case-control study of 310 colorectal cancer cases and 1177 controls in a nested prospective, population-based cohort of Singapore Chinese subjects found a statistically significant association between the cyclooxygenase (COX)-2 -765G>C gene polymorphism and colon cancer risk among high consumers of dietary n-6 polyunsaturated fatty acids (odds ratio=2.38, 95% confidence interval=1.23-4.59).
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Case-Control Studies
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Colonic Neoplasms / etiology*
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Cyclooxygenase 2
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Dietary Fats, Unsaturated* / adverse effects*
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Fatty Acids, Omega-6 / adverse effects*
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Female
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Humans
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Isoenzymes / genetics*
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Male
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Membrane Proteins
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Middle Aged
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Polymerase Chain Reaction
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Polymorphism, Genetic
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Prospective Studies
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Prostaglandin-Endoperoxide Synthases / genetics*
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Risk Factors
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Singapore
Substances
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Dietary Fats, Unsaturated
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Fatty Acids, Omega-6
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Isoenzymes
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Membrane Proteins
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Cyclooxygenase 2
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases