Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study

Br J Cancer. 2004 May 4;90(9):1760-4. doi: 10.1038/sj.bjc.6601797.

Abstract

This case-control study of 310 colorectal cancer cases and 1177 controls in a nested prospective, population-based cohort of Singapore Chinese subjects found a statistically significant association between the cyclooxygenase (COX)-2 -765G>C gene polymorphism and colon cancer risk among high consumers of dietary n-6 polyunsaturated fatty acids (odds ratio=2.38, 95% confidence interval=1.23-4.59).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Case-Control Studies
  • Colonic Neoplasms / etiology*
  • Cyclooxygenase 2
  • Dietary Fats, Unsaturated* / adverse effects*
  • Fatty Acids, Omega-6 / adverse effects*
  • Female
  • Humans
  • Isoenzymes / genetics*
  • Male
  • Membrane Proteins
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Prospective Studies
  • Prostaglandin-Endoperoxide Synthases / genetics*
  • Risk Factors
  • Singapore

Substances

  • Dietary Fats, Unsaturated
  • Fatty Acids, Omega-6
  • Isoenzymes
  • Membrane Proteins
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases