Abstract
Runt-related (RUNX) gene family is composed of three members, RUNX1/AML1, RUNX2 and RUNX3, and encodes the DNA-binding (alpha) subunits of the Runt domain transcription factor polyomavirus enhancer-binding protein 2 (PEBP2)/core-binding factor (CBF), which is a heterodimeric transcription factor. RUNX1 is most frequently involved in human acute leukemia. RUNX2 shows oncogenic potential in mouse experimental system. RUNX3 is a strong candidate as a gastric cancer tumor suppressor. The beta subunit gene of PEBP2/CBF is also frequently involved in chromosome rearrangements associated with human leukemia. In this Overview, I will summarize how this growing field has been formed and what are the challenging new frontiers for better understanding of the oncogenic potential of this gene family.
MeSH terms
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Animals
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Core Binding Factor Alpha 1 Subunit
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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Core Binding Factor alpha Subunits
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Core Binding Factors
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Humans
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Leukemia / genetics
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / metabolism
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Oncogenes / physiology*
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Protein Structure, Tertiary
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / metabolism
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Transcription Factors / genetics*
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Transcription Factors / metabolism
Substances
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Core Binding Factor Alpha 1 Subunit
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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Core Binding Factor alpha Subunits
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Core Binding Factors
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DNA-Binding Proteins
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Neoplasm Proteins
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Proto-Oncogene Proteins
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RUNX1 protein, human
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Runx3 protein, human
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Transcription Factors