Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans

Neurosci Lett. 2004 Jun 10;363(2):154-6. doi: 10.1016/j.neulet.2004.03.065.

Abstract

Association studies of the serotonin transporter (SLC6A4) gene in obsessive-compulsive disorder (OCD) have generated discrepant results. Here, we genotyped the 5-HTTLPR polymorphism in 106 French OCD patients and 171 healthy controls (case control study). We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Carrier Proteins / genetics*
  • Case-Control Studies
  • DNA Mutational Analysis
  • Family Health
  • Female
  • France / epidemiology
  • Gene Frequency*
  • Genetic Linkage*
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • Germany / epidemiology
  • Humans
  • Male
  • Membrane Glycoproteins / genetics*
  • Membrane Transport Proteins*
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Obsessive-Compulsive Disorder / epidemiology
  • Obsessive-Compulsive Disorder / genetics*
  • Polymorphism, Genetic / genetics*
  • Serotonin Plasma Membrane Transport Proteins
  • White People / genetics

Substances

  • Carrier Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins