Aim: To explore whether the activation-induced cytidine deaminase(AICDA) gene 8408 C/T polymorphism is related to adult atopic asthma and the level of plasma IgE.
Methods: The polymorphism of AICDA gene was detected by PCR and restriction fragment length polymorphism (PCR-RFLP).
Results: The frequencies of 8408T/T genotype had significant difference (P<0.05) between adult asthma patients and control group, while the frequencies of T allele between two groups were not significantly different. The total plasma IgE level in adult atopic asthma patients with 8408T/T genotype was higher than that in the patients with C/C and C/T genotypes(P<0.05).
Conclusion: The 8408 T/T genotype of AICDA is correlated with atopic asthma and total plasma IgE level in adult.