Abstract
We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC).
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Biomarkers, Tumor / genetics*
-
Blotting, Northern
-
Carcinoma, Squamous Cell / genetics*
-
Carcinoma, Squamous Cell / metabolism
-
Carcinoma, Squamous Cell / pathology
-
Cell Differentiation
-
Genes, Tumor Suppressor*
-
Head and Neck Neoplasms / genetics*
-
Head and Neck Neoplasms / metabolism
-
Head and Neck Neoplasms / pathology
-
Homeodomain Proteins / genetics*
-
Homeodomain Proteins / metabolism
-
Humans
-
In Situ Hybridization
-
RNA, Messenger / metabolism
-
Reverse Transcriptase Polymerase Chain Reaction
-
Tumor Suppressor Proteins
Substances
-
Biomarkers, Tumor
-
HOPX protein, human
-
Homeodomain Proteins
-
RNA, Messenger
-
Tumor Suppressor Proteins