Abstract
Pituitary tumors secreting growth hormone are clonal neoplasms that may arise following a somatic mutation within the somatotroph cell. Promotion of tumor growth also appears to be regulated by hypothalamic growth hormone-releasing hormone, which exerts a trophic action on the pituitary cell. Unraveling the mechanisms of pituitary tumorigenesis will facilitate the application of novel therapeutic techniques, genetic screening, and follow-up of tumor responses.
MeSH terms
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Acromegaly / etiology*
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Adenoma / complications*
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Adenoma / genetics
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Adenoma / metabolism
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Adenoma / physiopathology
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Animals
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Growth Hormone-Releasing Hormone / metabolism
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Humans
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Hypothalamus / physiopathology
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Oncogenes
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Pituitary Hormones, Anterior / metabolism
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Pituitary Neoplasms / complications*
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Pituitary Neoplasms / genetics
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Pituitary Neoplasms / metabolism
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Pituitary Neoplasms / physiopathology
Substances
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Pituitary Hormones, Anterior
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Growth Hormone-Releasing Hormone