Study objective: To evaluate the effect of induced hypotension with isoflurane or prostaglandin E(1) (PGE(1)) on cytokine responses to surgery.
Design: Prospective, randomized study.
Setting: University hospital.
Patients: 24 ASA physical status I and II patients undergoing elective oral and maxillofacial surgery.
Interventions: Patients were randomly allocated to three groups be anesthetized in the normotension (Control group), isoflurane-induced hypotension (Isoflurane-H group), and PGE(1)-induced hypotension (PGE(1)-H group). Mean arterial pressure during hypotension was maintained at approximately 80% of baseline values.
Measurements and main results: Blood samples were taken before induction of anesthesia and during and after hypotension. Plasma tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels were measured using enzyme-linked immunosorbent assay. There were no differences in TNF-alpha or IL-10 levels among the groups. However, the elevation of the plasma IL-6 level in the PGE(1)-H group was found during hypotension, compared with the control group (p < 0.05).
Conclusions: PGE(1)-induced hypotension has an effect on IL-6 response to oral and maxillofacial surgery.