Abstract
In an effort to identify host proteins involved in herpes simplex virus type 1 replication, monkey and human cellular protein activities (called OF-1) that bind the viral replication origin, oriS, have been described. We show by mass spectrometry that the DNA-binding component of human OF-1 contains Ku70 and Ku80 proteins.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Antigens, Nuclear / chemistry*
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Antigens, Nuclear / metabolism
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / metabolism*
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Dimerization
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Herpesvirus 1, Human / physiology
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Humans
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Ku Autoantigen
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Molecular Sequence Data
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Replication Origin / genetics
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Replication Origin / physiology*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
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Viral Proteins / metabolism
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Virus Replication
Substances
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Antigens, Nuclear
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DNA-Binding Proteins
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OF-1 protein
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Viral Proteins
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Xrcc6 protein, human
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Ku Autoantigen