Abstract
Laboratory methods to detect both FIP1L1-PDGFRA and c-kit D816V mutations were combined with immunomagnetic cell separation to study the extent of clonal involvement by both myeloid and lymphoid cells in 3 patients with systemic mastocytosis associated with eosinophilia. The results suggested an early stem cell origin for the FIP1L1-PDGFRA mutation.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged, 80 and over
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Eosinophilia / complications
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Eosinophilia / genetics
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Female
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Humans
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Male
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Mastocytosis, Systemic / blood
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Mastocytosis, Systemic / complications
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Mastocytosis, Systemic / genetics*
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Middle Aged
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Mutation
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Oncogene Proteins, Fusion / genetics*
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Proto-Oncogene Proteins c-kit / genetics*
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Receptor, Platelet-Derived Growth Factor alpha / genetics*
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mRNA Cleavage and Polyadenylation Factors / genetics*
Substances
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Oncogene Proteins, Fusion
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mRNA Cleavage and Polyadenylation Factors
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FIP1L1-PDGFRA fusion protein, human
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Proto-Oncogene Proteins c-kit
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Receptor, Platelet-Derived Growth Factor alpha