Abstract
The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARbeta and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenocarcinoma / genetics*
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Adenocarcinoma / pathology*
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Aged
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Carcinoma, Non-Small-Cell Lung / genetics*
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Carcinoma, Non-Small-Cell Lung / pathology*
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DNA Methylation*
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DNA, Neoplasm / metabolism*
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Female
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Genes, p16*
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Humans
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Lung Neoplasms / genetics*
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Lung Neoplasms / pathology*
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Male
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Middle Aged
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Retrospective Studies
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Survival Analysis